GoldBEAM
From DNA sequence to 3D structure, with the reasoning attached
GoldBEAM takes 1,048,576 bp of human DNA sequence and predicts its chromatin contact map at 2,048 bp resolution: domains, boundaries and the contacts between them. No Hi-C data is needed at inference time.
01
Sequence in
Submit 1,048,576 bp of human DNA through the research TUI or portal. No experimental data required.
02
Contact map out
A 448 × 448 map at 2,048 bp resolution covering the central 917 kb, predicted in a single forward pass.
03
Golden beams
Attribution traces each predicted contact back to the parts of the sequence responsible.
The name
Golden beams of truth
We picture the model's interpretability vectors as golden beams: lines of evidence running from a predicted contact back to the sequence that caused it. That is the point of the platform. A prediction you cannot explain is hard to trust and harder to publish.
In a contact map, each pixel is the predicted contact probability between two genomic loci. The diagonal is local proximity. The bright square blocks are TADs, the domains where gene regulation happens.
Illustrative contact map of the BRCA1 locus. Real GoldBEAM predictions will be published with pilot results.
Research Suite
A full interpretability lab in your terminal
The GoldBEAM TUI ships with seven built-in experiments, not just predictions. Run CTCF motif deletion sweeps, map TAD boundary attribution, design synthetic insulators and overlay empirical Hi-C data against model output.
Every result is logged to a structured report you can take straight into your analysis.