GoldBEAM
From DNA sequence to 3D structure, with the reasoning attached
GoldBEAM takes 1,048,576 bp of human DNA sequence and predicts its chromatin contact map at 2,048 bp resolution: domains, boundaries and the contacts between them. No Hi-C data is needed at inference time.
01
Sequence in
Submit 1,048,576 bp of human DNA through the research TUI or portal. No experimental data required.
02
Contact map out
A 448 × 448 map at 2,048 bp resolution covering the central 917 kb, predicted in a single forward pass.
03
Golden beams
Attribution traces each predicted contact back to the parts of the sequence responsible.
The name
Golden beams of truth
We picture the model's interpretability vectors as golden beams: lines of evidence running from a predicted contact back to the sequence that caused it. That is the point of the platform. A prediction you cannot explain is hard to trust and harder to publish.
In a contact map, each pixel shows how often two stretches of the genome touch. The map here is real measured Hi-C, shown relative to what genomic distance alone would predict, so the domains stand out as blocks along the diagonal: TADs, the neighbourhoods where gene regulation happens.
Measured Hi-C from HFF cells (DNALongBench validation data) at GoldBEAM's output resolution: 448 × 448 bins of 2,048 bp. Experimental data, not a GoldBEAM prediction.
Research Suite
A full interpretability lab in your terminal
The GoldBEAM TUI ships with nine built-in tools, not just predictions: sequence analytics, biophysical profiling, a composition check against the human training data, virtual CTCF deletion probes, and insulation and boundary scans.
Results export as structured reports and bedGraph tracks you can take straight into your analysis.